How Long After Taking Excedrin Can You Drink?


Excedrin, a widely used over-the-counter medication, combines acetaminophen, aspirin, and caffeine for effective pain relief. While generally safe, questions arise about the safety of consuming alcohol after taking Excedrin. This article delves into the effects of this combination on the body and addresses the crucial question of when it is safe to drink following Excedrin consumption.

Overview of Excedrin’s Mechanism:

Excedrin’s three active ingredients—acetaminophen, aspirin, and caffeine—synergize to provide rapid pain relief. Acetaminophen and aspirin alleviate pain and reduce inflammation, while caffeine enhances their effects.

Combining Excedrin and Alcohol:

Although it’s generally advised to avoid alcohol while on medication, moderate consumption of Excedrin and alcohol is permissible. However, caution is warranted as this pairing can potentially harm the liver, increasing the risk of liver damage.

Side Effects of the Combination:

Mixing Excedrin and alcohol heightens the risk of liver damage, gastrointestinal bleeding, stomach ulcers, and intensifies common Excedrin side effects such as dizziness and drowsiness.

Wait Time Before Drinking:

To minimize risks, it is recommended to wait at least 24 hours after taking Excedrin before consuming alcohol. This timeframe allows for complete metabolism and clearance of the medication from the system.

Safe Consumption Tips:

If alcohol consumption is necessary after Excedrin, moderation is key—limiting intake to one or two drinks. Additionally, avoid drinking on an empty stomach, stay hydrated, and refrain from mixing different types of alcohol.

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Excedrin, a widely used pain relief medication, can be safely taken, but caution is required when combining it with alcohol. Waiting at least 24 hours after Excedrin intake before drinking helps mitigate potential risks. Moderation and careful consideration of individual health conditions remain essential for a safe experience.


How long should I wait to drink alcohol after taking aspirin?

It is generally recommended to wait at least 4-6 hours after taking aspirin before consuming alcohol, considering aspirin’s potential to irritate the stomach lining and increase bleeding risks.

How long after drinking alcohol can I take Excedrin?

Waiting at least 8 hours after alcohol consumption before taking Excedrin, which contains acetaminophen, is advisable to reduce the risk of liver damage.

How long do I wait before drinking alcohol if I took ibuprofen?

Waiting at least 4-6 hours after taking ibuprofen before drinking alcohol is recommended to minimize the risk of stomach irritation and bleeding.

What happens if you mix beer and aspirin?

Combining beer and aspirin increases the risk of stomach irritation, bleeding, and liver damage due to the cumulative effects on the stomach lining and liver metabolism. It’s advisable to avoid this combination or wait before consuming alcohol after taking aspirin.